After the catastrophic events between Inhuman Pyro and The Cryo at Trafalgar Square, Kevin is framed for murder while The Super Six go into hiding as they are labelled "Britain's Most Wanted" by the UK Government, whilst an old foe, Corrie Pyrina, returns to unite with a man named Kane Murdock also known as The Powershifter, to assemble an underground team to take down the Inhuman Pyro, whilst Corrie Pyrina plots to bring an alien invasion that would annihilate all.